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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50219348
Substrate
n/a
Meas. Tech.
ChEMBL_2063643 (CHEMBL4718896)
IC50
87000±n/a nM
Citation
 Zur, AA; Chien, HC; Augustyn, E; Flint, A; Heeren, N; Finke, K; Hernandez, C; Hansen, L; Miller, S; Lin, L; Giacomini, KM; Colas, C; Schlessinger, A; Thomas, AA LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorg Med Chem Lett 26:5000-5006 (2016) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50219348
Synonyms:
(2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leucine | (S)-leucine | CHEMBL291962 | L-Leucin | L-Leuzin | L-leucine
Type:
Small organic molecule
Emp. Form.:
C6H13NO2
Mol. Mass.:
131.1729
SMILES:
CC(C)C[C@H](N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: