Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50120769
Substrate
n/a
Meas. Tech.
ChEMBL_31250 (CHEMBL642374)
Ki
>10000±n/a nM
Citation
 Novellino, E; Abignente, E; Cosimelli, B; Greco, G; Iadanza, M; Laneri, S; Lavecchia, A; Rimoli, MG; Settimo, FD; Primofiore, G; Tuscano, D; Trincavelli, L; Martini, C Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists. J Med Chem 45:5030-6 (2002) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50120769
Synonyms:
Benzyl-(7-methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-yl)-amine | CHEMBL148088
Type:
Small organic molecule
Emp. Form.:
C19H17N5
Mol. Mass.:
315.3718
SMILES:
Cc1cn2c(NCc3ccccc3)nc(nc2n1)-c1ccccc1
Structure:
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