Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50120761
Substrate
n/a
Meas. Tech.
ChEMBL_30745 (CHEMBL649776)
Ki
4300±n/a nM
Citation
 Novellino, E; Abignente, E; Cosimelli, B; Greco, G; Iadanza, M; Laneri, S; Lavecchia, A; Rimoli, MG; Settimo, FD; Primofiore, G; Tuscano, D; Trincavelli, L; Martini, C Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists. J Med Chem 45:5030-6 (2002) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50120761
Synonyms:
CHEMBL355898 | Cyclopentanecarboxylic acid (7-methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-yl)-amide
Type:
Small organic molecule
Emp. Form.:
C18H19N5O
Mol. Mass.:
321.3764
SMILES:
Cc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Structure:
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