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Target
Far upstream element-binding protein 1
Ligand
BDBM50558621
Substrate
n/a
Meas. Tech.
ChEMBL_2064177 (CHEMBL4719430)
IC50
11000±n/a nM
Citation
 Hauck, S; Hiesinger, K; Khageh Hosseini, S; Achenbach, J; Biondi, RM; Proschak, E; Zörnig, M; Odadzic, D Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors. Bioorg Med Chem 24:5717-5729 (2016) [PubMed]  Article 
Target
Name:
Far upstream element-binding protein 1
Synonyms:
DNA helicase V | FBP | FUBP1 | FUBP1_HUMAN | FUSE-binding protein 1 | Far upstream element-binding protein 1 | hDH V
Type:
PROTEIN
Mol. Mass.:
67565.13
Organism:
Homo sapiens
Description:
ChEMBL_118167
Residue:
644
Sequence:
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGPVNPLGPPVPHGPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHGPPAPYAPQGWGNAYPHWQQQAPPDPAKAGTDPNSAAWAAYYAHYYQQQAQPPPAAPAGAPTTTQTNGQGDQQNPAPAGQVDYTKAWEEYYKKMGQAVPAPTGAPPGGQPDYSAAWAEYYRQQAAYYAQTSPQGMPQHPPAPQGQ
  
Inhibitor
Name:
BDBM50558621
Synonyms:
CHEMBL4756599
Type:
Small organic molecule
Emp. Form.:
C19H14F3N3O2S
Mol. Mass.:
405.394
SMILES:
COc1ccc(cc1OC)-c1cc(n2nc(cc2n1)-c1cccs1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: