Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50122793
Substrate
n/a
Meas. Tech.
ChEMBL_72358 (CHEMBL686445)
IC50
700±n/a nM
Citation
 Wei, CQ; Gao, Y; Lee, K; Guo, R; Li, B; Zhang, M; Yang, D; Burke, TR Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems. J Med Chem 46:244-54 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
Grb2-SH2 | GRB2 adapter protein | Growth factor receptor-bound protein 2 | GRB2_HUMAN | GRB2 | ASH
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Human
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50122793
Synonyms:
{4-[3-Carbamoylmethyl-14-(2,3-dihydro-naphthalen-1-ylmethyl)-6,6-dimethyl-2,5,8-trioxo-1,4,7triaza-cyclopentadec-11-en-10-yl]-benzyl}-phosphonic acid | CHEMBL313407
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC1(C)NC(=O)C[C@H](\C=C\C[C@@H](CC2=c3ccccc3=CCC2)CNC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(CP(O)(O)=O)cc1 |c:13,20,t:8|
Structure:
Search PDB for entries with ligand similarity: