Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50122795
Substrate
n/a
Meas. Tech.
ChEMBL_72358 (CHEMBL686445)
IC50
>10000±n/a nM
Citation
 Wei, CQ; Gao, Y; Lee, K; Guo, R; Li, B; Zhang, M; Yang, D; Burke, TR Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems. J Med Chem 46:244-54 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
Grb2-SH2 | GRB2 adapter protein | Growth factor receptor-bound protein 2 | GRB2_HUMAN | GRB2 | ASH
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Human
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50122795
Synonyms:
[4-(19-Carbamoylmethyl-15-naphthalen-1-ylmethyl-8,18,21-trioxo-7,17,20-triaza-spiro[5.15]henicos-12-en-10-yl)-benzyl]-phosphonic acid | CHEMBL315337
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)C[C@H](C\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1 |t:21|
Structure:
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