Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50561615
Substrate
n/a
Meas. Tech.
ChEMBL_2075518 (CHEMBL4731052)
Ki
26000±n/a nM
Citation
 Shen, S; Doubleday, PF; Weerawarna, PM; Zhu, W; Kelleher, NL; Silverman, RB Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. ACS Med Chem Lett 11:1949-1955 (2020) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
GABT_PIG | ABAT | GABAT | GABA-AT | 4-aminobutyrate aminotransferase, mitochondrial | L-AIBAT | GABA aminotransferase | 2.6.1.19 | (S)-3-amino-2-methylpropionate transaminase | GABA transaminase | GABA-T | 2.6.1.22 | Gamma-amino-N-butyrate transaminase
Type:
n/a
Mol. Mass.:
56633.06
Organism:
Pig
Description:
n/a
Residue:
500
Sequence:
MASVLLTRRLACSFRHNHRLLVPGWRHISQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM50561615
Synonyms:
CHEMBL4747359
Type:
Small organic molecule
Emp. Form.:
C6H8FNO2
Mol. Mass.:
145.13
SMILES:
N[C@H]1C=C(C[C@@H]1F)C(O)=O |r,c:2|
Structure:
Search PDB for entries with ligand similarity: