Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50124990
Substrate
n/a
Meas. Tech.
ChEMBL_49131 (CHEMBL660271)
KON
0.000003 M-1s-1
Citation
 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors. Bioorg Med Chem Lett 13:723-8 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | FA10_HUMAN | F10
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Human
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50124990
Synonyms:
N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[2-oxo-4-(quinoline-8-sulfonyl)-piperazin-1-yl]-acetamide | CHEMBL355376
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: