Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50124995
Substrate
n/a
Meas. Tech.
ChEMBL_48985 (CHEMBL875895)
KOFF
0.190000 s-1
Citation
 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors. Bioorg Med Chem Lett 13:723-8 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | FA10_HUMAN | F10
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Human
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50124995
Synonyms:
2-[4-(4-Chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[(R)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide | CHEMBL159695
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NC(=N)NCCC[C@@H](NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1ccc(Cl)cc1)C(=O)c1nccs1
Structure:
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