Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50562972
Substrate
n/a
Meas. Tech.
ChEMBL_2081163 (CHEMBL4736954)
Ki
0.250000±n/a nM
Citation
 Mboge, MY; Combs, J; Singh, S; Andring, J; Wolff, A; Tu, C; Zhang, Z; McKenna, R; Frost, SC Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. J Med Chem 64:1713-1724 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50562972
Synonyms:
CHEMBL4799997
Type:
Small organic molecule
Emp. Form.:
C15H13F2N3O3S
Mol. Mass.:
353.344
SMILES:
NS(=O)(=O)c1ccc(cc1)N1CCN(C1=O)c1ccc(F)cc1F
Structure:
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