Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM50563889
Substrate
n/a
Meas. Tech.
ChEMBL_2085159 (CHEMBL4766422)
IC50
1.000000±n/a nM
Citation
 Debenham, JS; Madsen-Duggan, C; Clements, MJ; Walsh, TF; Kuethe, JT; Reibarkh, M; Salowe, SP; Sonatore, LM; Hajdu, R; Milligan, JA; Visco, DM; Zhou, D; Lingham, RB; Stickens, D; DeMartino, JA; Tong, X; Wolff, M; Pang, J; Miller, RR; Sherer, EC; Hale, JJ Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem 59:11039-11049 (2016) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50563889
Synonyms:
CHEMBL4783524
Type:
Small organic molecule
Emp. Form.:
C24H21N5O4
Mol. Mass.:
443.4546
SMILES:
COc1ccc(cc1)C(NC(=O)c1cnc(nc1O)-c1cccnn1)c1ccc(OC)cc1
Structure:
Search PDB for entries with ligand similarity: