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Target
Histone deacetylase 8
Ligand
BDBM50534338
Substrate
n/a
Meas. Tech.
ChEMBL_2089699 (CHEMBL4770962)
IC50
0.800000±n/a nM
Citation
 Ghazy, E; Zeyen, P; Herp, D; Hügle, M; Schmidtkunz, K; Erdmann, F; Robaa, D; Schmidt, M; Morales, ER; Romier, C; Günther, S; Jung, M; Sippl, W Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem 200:0 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 | HDAC8_HUMAN | HDAC8 | HDACL1
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Human
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50534338
Synonyms:
CHEMBL4534486
Type:
Small organic molecule
Emp. Form.:
C22H20N4O2
Mol. Mass.:
372.43
SMILES:
ONC(=O)[C@H](Cc1ccccc1)n1nnc(c1C#CC1CC1)-c1ccccc1 |r|
Structure:
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