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Target
Histone deacetylase 3
Ligand
BDBM50510962
Substrate
n/a
Meas. Tech.
ChEMBL_2089731 (CHEMBL4770994)
IC50
5.0±n/a nM
Citation
 Ghazy, E; Zeyen, P; Herp, D; Hügle, M; Schmidtkunz, K; Erdmann, F; Robaa, D; Schmidt, M; Morales, ER; Romier, C; Günther, S; Jung, M; Sippl, W Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem 200:0 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Human
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50510962
Synonyms:
CHEMBL4454646
Type:
Small organic molecule
Emp. Form.:
C27H30FN3O3
Mol. Mass.:
463.55
SMILES:
Cc1noc(C)c1-c1ccc2n(CCCCCCC(=O)NO)cc(Cc3ccc(F)cc3)c2c1
Structure:
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