Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM422376
Substrate
n/a
Meas. Tech.
ChEMBL_2102447 (CHEMBL4810843)
EC50
5.0±n/a nM
Citation
 Tora, G; Jiang, J; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; Xu, C; Galella, MA; Wang, T; He, Y; Wexler, RR; Finlay, HJ Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists. Bioorg Med Chem Lett 50:0 (2021) [PubMed]  Article 
Target
Name:
Apelin receptor
Synonyms:
APJ_MOUSE | Agtrl1 | Angiotensin receptor-like 1 | Apj | Aplnr | G-protein coupled receptor APJ | MSR
Type:
PROTEIN
Mol. Mass.:
42269.53
Organism:
Mus musculus
Description:
ChEMBL_120488
Residue:
377
Sequence:
MEDDGYNYYGADNQSECDYADWKPSGALIPAIYMLVFLLGTTGNGLVLWTVFRTSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDASENGTKIQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDIFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCDQSGCKGTPHSSSAEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVD
  
Inhibitor
Name:
BDBM422376
Synonyms:
5-(4- cyclopropylbenzene- sulfonyl)-1-(2,6- dimethoxyphenyl)-6- hydroxy-2-(5- methylpyridin-3-yl)- 1,4-dihydropyrimidin-4- one | US10508104, Example 277
Type:
Small organic molecule
Emp. Form.:
C27H25N3O6S
Mol. Mass.:
519.569
SMILES:
COc1cccc(OC)c1-n1c(O)c(c(=O)nc1-c1cncc(C)c1)S(=O)(=O)c1ccc(cc1)C1CC1 |(-6.18,-2.31,;-4.85,-1.54,;-3.51,-2.31,;-3.51,-3.85,;-2.18,-4.62,;-.85,-3.85,;-.85,-2.31,;.49,-1.54,;1.82,-2.31,;-2.18,-1.54,;-2.18,,;-.85,.77,;.49,,;-.85,2.31,;-2.18,3.08,;-2.18,4.62,;-3.51,2.31,;-3.51,.77,;-4.85,,;-5.62,-1.33,;-7.16,-1.33,;-7.93,,;-7.16,1.33,;-7.93,2.67,;-5.62,1.33,;.49,3.08,;-.28,4.41,;1.26,4.41,;1.98,2.68,;2.37,1.19,;3.86,.8,;4.95,1.88,;4.55,3.37,;3.06,3.77,;6.44,1.49,;7.53,.4,;7.93,1.88,)|
Structure:
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