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Target
Dual specificity mitogen-activated protein kinase kinase 4
Ligand
BDBM50567688
Substrate
n/a
Meas. Tech.
ChEMBL_2103768 (CHEMBL4812271)
IC50
89±n/a nM
Citation
 Pfaffenrot, B; Klövekorn, P; Juchum, M; Selig, R; Albrecht, W; Zender, L; Laufer, SA Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms:
JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1
Type:
PROTEIN
Mol. Mass.:
44294.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1460558
Residue:
399
Sequence:
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
  
Inhibitor
Name:
BDBM50567688
Synonyms:
CHEMBL4784779
Type:
Small organic molecule
Emp. Form.:
C22H19F2N5O5S2
Mol. Mass.:
535.544
SMILES:
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(cc23)-c2ccc(cc2)S(N)(=O)=O)c1F
Structure:
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