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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50132413
Substrate
n/a
Meas. Tech.
ChEMBL_124492 (CHEMBL733328)
Kd
14±n/a nM
Citation
 Regan, J; Pargellis, CA; Cirillo, PF; Gilmore, T; Hickey, ER; Peet, GW; Proto, A; Swinamer, A; Moss, N The kinetics of binding to p38MAP kinase by analogues of BIRB 796. Bioorg Med Chem Lett 13:3101-4 (2003) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50132413
Synonyms:
1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[3-methoxy-4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | CHEMBL104973
Type:
Small organic molecule
Emp. Form.:
C32H39N5O4
Mol. Mass.:
557.6832
SMILES:
COc1cc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc2c1OCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: