Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50511585
Substrate
n/a
Meas. Tech.
ChEMBL_2104706 (CHEMBL4813209)
Ki
6925±n/a nM
Citation
 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. Bioorg Med Chem Lett 45:0 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50511585
Synonyms:
CHEMBL4471819
Type:
Small organic molecule
Emp. Form.:
C16H19NO5STe
Mol. Mass.:
465
SMILES:
[#6]-[#8]-c1cc([Te;v2][#6]-c2ccc(cc2)S([#7])(=O)=O)cc(-[#8]-[#6])c1-[#8]-[#6]
Structure:
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