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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50568230
Substrate
n/a
Meas. Tech.
ChEMBL_2104887 (CHEMBL4813390)
IC50
1300±n/a nM
Citation
 Petrovi?, MM; Roschger, C; Chaudary, S; Zierer, A; Mladenovi?, M; Markovi?, V; Trifunovi?, S; Joksovi?, MD Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors. Bioorg Med Chem Lett 46:0 (2021) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50568230
Synonyms:
CHEMBL4859051
Type:
Small organic molecule
Emp. Form.:
C25H19ClN2O5
Mol. Mass.:
462.882
SMILES:
COc1cc(ccc1OCC(=O)Nc1ccccc1Cl)-c1cc(C(O)=O)c2ccccc2n1
Structure:
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