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Target
Dual specificity mitogen-activated protein kinase kinase 4
Ligand
BDBM50568579
Substrate
n/a
Meas. Tech.
ChEMBL_2105912 (CHEMBL4814587)
Kd
0.850000±n/a nM
Citation
 Klövekorn, P; Pfaffenrot, B; Juchum, M; Selig, R; Albrecht, W; Zender, L; Laufer, SA From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4). Eur J Med Chem 210:0 (2021) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms:
C-JUN N-terminal kinase kinase 1 | JNK kinase 1 | JNK-activating kinase 1 | JNKK 1 | Jnkk1 | MAP kinase kinase 4 | MAPK/ERK kinase 4 | MAPKK 4 | MP2K4_MOUSE | Map2k4 | Mek4 | Mkk4 | Prkmk4 | SAPK/ERK kinase 1 | Sek1 | Serk1 | Skk1
Type:
PROTEIN
Mol. Mass.:
44120.14
Organism:
Mus musculus
Description:
EBI_11048
Residue:
397
Sequence:
MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
  
Inhibitor
Name:
BDBM50568579
Synonyms:
CHEMBL4848804
Type:
Small organic molecule
Emp. Form.:
C26H20FN5O4S
Mol. Mass.:
517.532
SMILES:
COc1ncc(cn1)-c1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1
Structure:
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