Target
Dual specificity mitogen-activated protein kinase kinase 4
Ligand
BDBM50568579
Substrate
n/a
Meas. Tech.
ChEMBL_2105912
Kd
0.850000±n/a nM
Citation
 Klövekorn, PPfaffenrot, BJuchum, MSelig, RAlbrecht, WZender, LLaufer, SA From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4). Eur J Med Chem 210:0 (2021) [PubMed]
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms:
C-JUN N-terminal kinase kinase 1 | JNK kinase 1 | JNK-activating kinase 1 | JNKK 1 | MAP kinase kinase 4 | MAPK/ERK kinase 4 | MAPKK 4 | SAPK/ERK kinase 1 | SEK1
Type:
PROTEIN
Mol. Mass.:
44120.14
Organism:
Mus musculus
Description:
EBI_11048
Residue:
397
Sequence:
MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
  
Inhibitor
Name:
BDBM50568579
Synonyms:
CHEMBL4848804
Type:
Small organic molecule
Emp. Form.:
C26H20FN5O4S
Mol. Mass.:
517.532
SMILES:
COc1ncc(cn1)-c1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1
Structure:
Search PDB for entries with ligand similarity: