Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50568918
Substrate
n/a
Meas. Tech.
ChEMBL_2106949 (CHEMBL4815624)
Ki
1660±n/a nM
Citation
 Ofori, E; Onyameh, EK; Gonela, UM; Voshavar, C; Bricker, B; Swanson, TL; Eshleman, AJ; Schmachtenberg, JL; Bloom, SH; Janowsky, AJ; Ablordeppey, SY New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263. Eur J Med Chem 214:0 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin receptor 2C
Type:
PROTEIN
Mol. Mass.:
51820.72
Organism:
Homo sapiens
Description:
ChEMBL_104992
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50568918
Synonyms:
CHEMBL4854456
Type:
Small organic molecule
Emp. Form.:
C20H21Cl2N3O
Mol. Mass.:
390.306
SMILES:
Clc1cc2CC(CCN3CCN(CC3)c3ccccn3)C(=O)c2cc1Cl
Structure:
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