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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50130293
Substrate
n/a
Meas. Tech.
ChEMBL_2112206 (CHEMBL4821056)
Ki
18±n/a nM
Citation
 Gao, L; Hao, C; Chen, J; Ma, R; Zheng, L; Wu, Q; Liu, X; Liu, BF; Zhang, G; Chen, Y; Jin, J Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect. Bioorg Med Chem Lett 40:0 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin receptor 2C
Type:
PROTEIN
Mol. Mass.:
51820.72
Organism:
Homo sapiens
Description:
ChEMBL_104992
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50130293
Synonyms:
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one | ARIPIPRAZOLE | CHEMBL1112 | US10174011, aripiprazole | US10752588, Compound Aripiprazole | US11498896, Compound Aripiprazole | US9018213, aripprazole | US9156822, Aripiprazole
Type:
Small organic molecule
Emp. Form.:
C23H27Cl2N3O2
Mol. Mass.:
448.385
SMILES:
Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Structure:
Search PDB for entries with ligand similarity: