Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50487259
Substrate
n/a
Meas. Tech.
ChEMBL_2113158 (CHEMBL4822008)
Ki
2.6±n/a nM
Citation
 Cordone, P; Namballa, HK; Muniz, B; Pal, RK; Gallicchio, E; Harding, WW New tetrahydroisoquinoline-based D Bioorg Med Chem Lett 42:0 (2021) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Human
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50487259
Synonyms:
CHEBI:64219 | [3H]NEMONAPRIDE
Type:
Small organic molecule
Emp. Form.:
C21H26ClN3O2
Mol. Mass.:
387.91
SMILES:
C[C@@H]1[C@@H](CCN1Cc2ccccc2)NC(=O)c3cc(c(cc3OC)NC)Cl
Structure:
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