Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 2 subunit 1
Ligand
BDBM50570964
Substrate
n/a
Meas. Tech.
ChEMBL_2113376 (CHEMBL4822226)
IC50
9.0±n/a nM
Citation
Calvo, V; Surguladze, D; Li, AH; Surman, MD; Malibhatla, S; Bandaru, M; Jonnalagadda, SK; Adarasandi, R; Velmala, M; Singireddi, DRP; Velpuri, M; Nareddy, BR; Sastry, V; Mandati, C; Guguloth, R; Siddiqui, S; Patil, BS; Chad, E; Wolfley, J; Gasparek, J; Feldman, K; Betzenhauser, M; Wiens, B; Koszelak-Rosenblum, M; Zhu, G; Du, H; Rigby, AC; Mulvihill, MJ Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett 43:0 (2021) [PubMed] Article
More Info.:
Target
Name:
Eukaryotic translation initiation factor 2 subunit 1
Synonyms:
EIF2A | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha | IF2A_HUMAN | eIF-2-alpha | eIF-2A | eIF-2alpha
Type:
PROTEIN
Mol. Mass.:
36100.17
Organism:
Homo sapiens
Description:
ChEMBL_103542
Residue:
315
Sequence:
MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED