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Target
Lon protease homolog, mitochondrial
Ligand
BDBM50571498
Substrate
n/a
Meas. Tech.
ChEMBL_2114930 (CHEMBL4823871)
IC50
109±n/a nM
Citation
 Kingsley, LJ; He, X; McNeill, M; Nelson, J; Nikulin, V; Ma, Z; Lu, W; Zhou, VW; Manuia, M; Kreusch, A; Gao, MY; Witmer, D; Vaillancourt, MT; Lu, M; Greenblatt, S; Lee, C; Vashisht, A; Bender, S; Spraggon, G; Michellys, PY; Jia, Y; Haling, JR; Lelais, G Structure-Based Design of Selective LONP1 Inhibitors for Probing  J Med Chem 64:4857-4869 (2021) [PubMed]  Article 
Target
Name:
Lon protease homolog, mitochondrial
Synonyms:
3.4.21.53 | LONHs | LONM_HUMAN | LONP | LONP1 | Lon protease homolog, mitochondrial | Lon protease-like protein | Mitochondrial ATP-dependent protease Lon | PRSS15 | Serine protease 15
Type:
PROTEIN
Mol. Mass.:
106485.52
Organism:
Homo sapiens
Description:
ChEMBL_120400
Residue:
959
Sequence:
MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER
  
Inhibitor
Name:
BDBM50571498
Synonyms:
CHEMBL4847335
Type:
Small organic molecule
Emp. Form.:
C22H23BN4O4
Mol. Mass.:
418.253
SMILES:
OB(O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1 |r|
Structure:
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