Reaction Details Report a problem with these data
Target
Holo-[acyl-carrier-protein] synthase
Ligand
BDBM50137227
Substrate
n/a
Meas. Tech.
ChEBML_88040
IC50
1100±n/a nM
Citation
 Gilbert, AM; Kirisits, M; Toy, P; Nunn, DS; Failli, A; Dushin, EG; Novikova, E; Petersen, PJ; Joseph-McCarthy, D; McFadyen, I; Fritz, CC Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors. Bioorg Med Chem Lett 14:37-41 (2003) [PubMed]  Article 
Target
Name:
Holo-[acyl-carrier-protein] synthase
Synonyms:
ACPS_BACSU | Holo-[acyl-carrieir-protein] synthase | acpS | ydcB
Type:
PROTEIN
Mol. Mass.:
13724.66
Organism:
Bacillus subtilis
Description:
ChEMBL_326222
Residue:
121
Sequence:
MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEKRKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVSITHTKEYAAAQVVIERLSS
  
Inhibitor
Name:
BDBM50137227
Synonyms:
5-Chloro-2-{[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazol-(4E)-ylidenemethyl]-amino}-benzoic acid | CHEMBL130278
Type:
Small organic molecule
Emp. Form.:
C18H9ClF4N2O4
Mol. Mass.:
428.722
SMILES:
OC(=O)c1cc(Cl)ccc1\N=C\c1nc(oc1O)-c1ccc(c(F)c1)C(F)(F)F
Structure:
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