Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50572652
Substrate
n/a
Meas. Tech.
ChEMBL_2117619 (CHEMBL4826685)
EC50
3300±n/a nM
Citation
 Ledneczki, IHorváth, ATapolcsányi, PÉles, JMolnár, KDVágó, IVisegrády, AKiss, LSzigetvári, ÁKóti, JKrámos, BMahó, SHolm, PKolok, SFodor, LThán, MKostyalik, DBalázs, OVastag, MGreiner, ILévay, GLendvai, BNémethy, Z HTS-based discovery and optimization of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor. Eur J Med Chem 222:0 (2021) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50572652
Synonyms:
CHEMBL4864942
Type:
Small organic molecule
Emp. Form.:
C22H24N4O2
Mol. Mass.:
376.4516
SMILES:
Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccn3cccc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: