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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50572664
Substrate
n/a
Meas. Tech.
ChEMBL_2117619 (CHEMBL4826685)
EC50
55±n/a nM
Citation
 Ledneczki, I; Horváth, A; Tapolcsányi, P; Éles, J; Molnár, KD; Vágó, I; Visegrády, A; Kiss, L; Szigetvári, Á; Kóti, J; Krámos, B; Mahó, S; Holm, P; Kolok, S; Fodor, L; Thán, M; Kostyalik, D; Balázs, O; Vastag, M; Greiner, I; Lévay, G; Lendvai, B; Némethy, Z HTS-based discovery and optimization of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor. Eur J Med Chem 222:0 (2021) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50572664
Synonyms:
CHEMBL4857691
Type:
Small organic molecule
Emp. Form.:
C21H22ClN3O2
Mol. Mass.:
383.871
SMILES:
Cn1ccc2cc(CNC(=O)N3CC(COc4ccc(Cl)cc4)C3)ccc12
Structure:
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