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Target
N6-adenosine-methyltransferase catalytic subunit
Ligand
BDBM50572907
Substrate
n/a
Meas. Tech.
ChEMBL_2118555 (CHEMBL4827621)
IC50
<10.0±n/a nM
Citation
 Sabnis, RW Novel METTL3 Modulators for Treating Acute Myeloid Leukemia (AML). ACS Med Chem Lett 12:1061-1062 (2021) [PubMed]  Article 
Target
Name:
N6-adenosine-methyltransferase catalytic subunit
Synonyms:
2.1.1.348 | METTL3 | MT-A70 | MTA70 | MTA70_HUMAN | Methyltransferase-like protein 3 | N6-adenosine-methyltransferase 70 kDa subunit | N6-adenosine-methyltransferase catalytic subunit | hMETTL3
Type:
PROTEIN
Mol. Mass.:
64471.71
Organism:
Homo sapiens
Description:
ChEMBL_120160
Residue:
580
Sequence:
MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
  
Inhibitor
Name:
BDBM50572907
Synonyms:
CHEMBL4850503
Type:
Small organic molecule
Emp. Form.:
C27H32N6O4
Mol. Mass.:
504.5808
SMILES:
CCNc1ccc2ccc(OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cc(C4CCCC4)c4c(N)ncnc34)cc2n1 |r|
Structure:
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