Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM29094
Substrate
n/a
Meas. Tech.
ChEMBL_46977 (CHEMBL659744)
Ki
>1000±n/a nM
Citation
 Lange, JH; Coolen, HK; van Stuivenberg, HH; Dijksman, JA; Herremans, AH; Ronken, E; Keizer, HG; Tipker, K; McCreary, AC; Veerman, W; Wals, HC; Stork, B; Verveer, PC; den Hartog, AP; de Jong, NM; Adolfs, TJ; Hoogendoorn, J; Kruse, CG Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem 47:627-43 (2004) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM29094
Synonyms:
(+/-)-SLV319 | (S)-3-(4-chlorophenyl)-N-(4-chlorophenylsulfonyl)-N'-methyl-4-phenyl-4,5-dihydropyrazole-1-carboxamidine | 3-(4-chlorophenyl)-N''''-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide | 4-Chloro-N-[1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylamino-meth-(E)-ylidene]-benzenesulfonamide | CHEMBL158784 | SLV-319 | ibipinabant
Type:
Small organic molecule
Emp. Form.:
C23H20Cl2N4O2S
Mol. Mass.:
487.402
SMILES:
CN=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:1.0,c:18|
Structure:
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