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Target
Programmed cell death 1 ligand/protein 1
Ligand
BDBM50573584
Substrate
n/a
Meas. Tech.
ChEMBL_2119765 (CHEMBL4828912)
EC50
104±n/a nM
Citation
 Wu, Y; Zhang, Y; Guo, Y; Pan, Z; Zhong, S; Jin, X; Zhuang, W; Chen, S; Gao, J; Huang, W; Dong, X; Che, J Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction. Eur J Med Chem 223:0 (2021) [PubMed]  Article 
Target
Name:
Programmed cell death 1 ligand/protein 1
Synonyms:
PD-1/PD-L1 | Programmed cell death protein 1/Programmed cell death 1 ligand 1
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | Programmed cell death protein 1 | Protein PD-1 | hPD-1 | PDCD1_HUMAN | PDCD1 | PD1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Human
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Component 2
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | CD_antigen=CD274 | PD-L1 | PDCD1 ligand 1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 | PD1L1_HUMAN | CD274 | B7H1 | PDCD1L1 | PDCD1LG1 | PDL1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Human
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50573584
Synonyms:
CHEMBL4845782
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: