Reaction Details Report a problem with these data
Target
Interleukin-17A
Ligand
BDBM50574355
Substrate
n/a
Meas. Tech.
ChEMBL_2122293 (CHEMBL4831440)
IC50
7.0±n/a nM
Citation
 Sabnis, RW Imidazo[1,2- ACS Med Chem Lett 12:1526-1527 (2021) [PubMed]  Article 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM50574355
Synonyms:
CHEMBL4874078
Type:
Small organic molecule
Emp. Form.:
C27H30F5N7O4
Mol. Mass.:
611.5636
SMILES:
COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1conc1C1CC1)C1CCC(F)(F)CC1 |r|
Structure:
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