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Target
Pannexin-1
Ligand
BDBM50574565
Substrate
n/a
Meas. Tech.
ChEMBL_2122674 (CHEMBL4831907)
IC50
4900±n/a nM
Citation
 Crocetti, L; Guerrini, G; Puglioli, S; Giovannoni, MP; Di Cesare Mannelli, L; Lucarini, E; Ghelardini, C; Wang, J; Dahl, G Design and synthesis of the first indole-based blockers of Panx-1 channel. Eur J Med Chem 223:0 (2021) [PubMed]  Article 
Target
Name:
Pannexin-1
Synonyms:
PANX1_MOUSE | Pannexin-1 | Panx1
Type:
PROTEIN
Mol. Mass.:
48168.73
Organism:
Mus musculus
Description:
ChEMBL_120484
Residue:
426
Sequence:
MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFVVILLACIYLSYYFSLSSLSDEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLSLINLIVYALLIPVVVYTFFIPFRQKTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQGSQRVEFKDLDLSSEAAANNGEKNSRQRLLNPSC
  
Inhibitor
Name:
BDBM50574565
Synonyms:
CHEMBL4858078
Type:
Small organic molecule
Emp. Form.:
C17H12N2O6
Mol. Mass.:
340.287
SMILES:
OC(=O)c1cc2cc(ccc2n1Cc1ccc(cc1)C(O)=O)[N+]([O-])=O
Structure:
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