Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50108877
Substrate
n/a
Meas. Tech.
ChEMBL_2124228 (CHEMBL4833461)
IC50
3200±n/a nM
Citation
 Yokoyama, T; Kashihara, M; Mizuguchi, M Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J Med Chem 64:14344-14357 (2021) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
Transthyretin (TTR) | ATTR | Prealbumin | TBPA | TTHY_HUMAN | TTR | PALB
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50108877
Synonyms:
CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone | Talcapone | (3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone | TOLCAPONE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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