Reaction Details Report a problem with these data
Target
Islet amyloid polypeptide
Ligand
BDBM50575509
Substrate
n/a
Meas. Tech.
ChEMBL_2125418 (CHEMBL4834763)
IC50
1200±n/a nM
Citation
 Hsu, JY; Rao Sathyan, A; Hsu, KC; Chen, LC; Yen, CC; Tseng, HJ; Wu, KC; Liu, HK; Huang, WJ Synthesis of Yakuchinone B-Inspired Inhibitors against Islet Amyloid Polypeptide Aggregation. J Nat Prod 84:1096-1103 (2021) [PubMed]  Article 
Target
Name:
Islet amyloid polypeptide
Synonyms:
Amylin | DAP | Diabetes-associated peptide | IAPP | IAPP_HUMAN | Insulinoma amyloid peptide | Islet amyloid polypeptide
Type:
PROTEIN
Mol. Mass.:
9813.88
Organism:
Homo sapiens
Description:
ChEMBL_104362
Residue:
89
Sequence:
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
  
Inhibitor
Name:
BDBM50575509
Synonyms:
CHEMBL4876955
Type:
Small organic molecule
Emp. Form.:
C19H20O4
Mol. Mass.:
312.3597
SMILES:
Oc1ccc(\C=C\C(=O)CCCCc2ccccc2O)cc1O
Structure:
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