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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM50576018
Substrate
n/a
Meas. Tech.
ChEMBL_2126195 (CHEMBL4835540)
IC50
10.0±n/a nM
Citation
 Konteatis, Z; Travins, J; Gross, S; Marjon, K; Barnett, A; Mandley, E; Nicolay, B; Nagaraja, R; Chen, Y; Sun, Y; Liu, Z; Yu, J; Ye, Z; Jiang, F; Wei, W; Fang, C; Gao, Y; Kalev, P; Hyer, ML; DeLaBarre, B; Jin, L; Padyana, AK; Dang, L; Murtie, J; Biller, SA; Sui, Z; Marks, KM Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous  J Med Chem 64:4430-4449 (2021) [PubMed]  Article 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM50576018
Synonyms:
CHEMBL4585665
Type:
Small organic molecule
Emp. Form.:
C28H25N5O3
Mol. Mass.:
479.5298
SMILES:
COc1ccc(cc1)-c1c(Nc2ccon2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1 |t:35|
Structure:
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