Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50142449
Substrate
n/a
Meas. Tech.
ChEBML_39489
IC50
39±n/a nM
Citation
 Varnes, JG; Gardner, DS; Santella, JB; Duncia, JV; Estrella, M; Watson, PS; Clark, CM; Ko, SS; Welch, P; Covington, M; Stowell, N; Wadman, E; Davies, P; Solomon, K; Newton, RC; Trainor, GL; Decicco, CP; Wacker, DA Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists. Bioorg Med Chem Lett 14:1645-9 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50142449
Synonyms:
1-(3-Acetyl-phenyl)-3-{3-[4-(4-fluoro-benzyl)-2-aza-bicyclo[2.2.2]oct-2-yl]-propyl}-urea | CHEMBL290276
Type:
Small organic molecule
Emp. Form.:
C26H32FN3O2
Mol. Mass.:
437.5496
SMILES:
CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 |(15.48,-4.82,;14.13,-4.05,;14.13,-2.51,;12.8,-4.82,;12.8,-6.38,;11.46,-7.15,;10.13,-6.38,;10.13,-4.82,;8.78,-4.03,;7.44,-4.8,;7.44,-6.36,;6.11,-4.03,;4.78,-4.8,;3.44,-4.03,;2.09,-4.82,;.76,-4.03,;.8,-2.65,;-.53,-2.11,;-1.63,-1.01,;-3.13,-1.41,;-4.27,-.72,;-5.45,-1.39,;-5.46,-2.74,;-6.63,-3.4,;-4.29,-3.42,;-3.13,-2.74,;-1.65,-2.83,;-1.77,-4.24,;-.65,-3.51,;-1.03,-1.62,;-.74,-.49,;11.46,-4.05,)|
Structure:
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