Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50142451
Substrate
n/a
Meas. Tech.
ChEBML_39489
IC50
2.6±n/a nM
Citation
Varnes, JG; Gardner, DS; Santella, JB; Duncia, JV; Estrella, M; Watson, PS; Clark, CM; Ko, SS; Welch, P; Covington, M; Stowell, N; Wadman, E; Davies, P; Solomon, K; Newton, RC; Trainor, GL; Decicco, CP; Wacker, DA Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists. Bioorg Med Chem Lett 14:1645-9 (2004) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
Inhibitor
Name:
BDBM50142451
Synonyms:
1-(3-((S)-3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-acetyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl)urea | 1-[3-Acetyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-3-{3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-propyl}-urea | CHEMBL295415
Type:
Small organic molecule
Emp. Form.:
C26H32FN7O2
Mol. Mass.:
493.5764
SMILES:
CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(c1)-c1nnnn1C