Reaction Details Report a problem with these data
Target
Immunoglobulin lambda variable 6-57
Ligand
BDBM50576187
Substrate
n/a
Meas. Tech.
ChEMBL_2126711 (CHEMBL4836056)
EC50
8800±n/a nM
Citation
 Yan, NL; Santos-Martins, D; Nair, R; Chu, A; Wilson, IA; Johnson, KA; Forli, S; Morgan, GJ; Petrassi, HM; Kelly, JW Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J Med Chem 64:6273-6299 (2021) [PubMed]  Article 
Target
Name:
Immunoglobulin lambda variable 6-57
Synonyms:
IGLV6-57 | Ig lambda chain V-VI region AR | Ig lambda chain V-VI region EB4 | Ig lambda chain V-VI region NIG-48 | Ig lambda chain V-VI region SUT | Ig lambda chain V-VI region WLT | Immunoglobulin lambda variable 6-57 | LV657_HUMAN
Type:
PROTEIN
Mol. Mass.:
12561.55
Organism:
Homo sapiens
Description:
ChEMBL_120180
Residue:
117
Sequence:
MAWAPLLLTLLAHCTGSWANFMLTQPHSVSESPGKTVTISCTGSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSN
  
Inhibitor
Name:
BDBM50576187
Synonyms:
CHEMBL4860180
Type:
Small organic molecule
Emp. Form.:
C23H33N3O4
Mol. Mass.:
415.5258
SMILES:
CCN(CC)c1ccc2c(C)c(CCOC(=O)NCC3CCCNC3)c(=O)oc2c1
Structure:
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