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Target
Glycine N-methyltransferase
Ligand
BDBM50576437
Substrate
n/a
Meas. Tech.
ChEMBL_2127252 (CHEMBL4836597)
IC50
240000±n/a nM
Citation
 Bobi?eva, O; Bobrovs, R; Ka?epe, I; Patetko, L; Kalni??, G; ?i?ovs, M; Bula, AL; Gri Nberga, S; Borodu??is, MR; Ramata-Stunda, A; Rostoks, N; Jirgensons, A; Ta Rs, K; Jaudzems, K Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate. ACS Med Chem Lett 12:1102-1107 (2021) [PubMed]  Article 
Target
Name:
Glycine N-methyltransferase
Synonyms:
2.1.1.20 | GNMT | GNMT_HUMAN | Glycine N-methyltransferase
Type:
PROTEIN
Mol. Mass.:
32744.92
Organism:
Homo sapiens
Description:
ChEMBL_119045
Residue:
295
Sequence:
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
  
Inhibitor
Name:
BDBM50576437
Synonyms:
CHEMBL4851408
Type:
Small organic molecule
Emp. Form.:
C16H21N7O6
Mol. Mass.:
407.3812
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(O)=O)CC1 |r|
Structure:
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