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Target
Interleukin-17A
Ligand
BDBM50578382
Substrate
n/a
Meas. Tech.
ChEMBL_2132782 (CHEMBL4842297)
IC50
2.0±n/a nM
Citation
 Sabnis, RW Novel Difluorocyclohexyl Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Diseases. ACS Med Chem Lett 12:1883-1884 (2021) [PubMed]  Article 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM50578382
Synonyms:
CHEMBL4865978
Type:
Small organic molecule
Emp. Form.:
C25H23F9N8O2
Mol. Mass.:
638.4881
SMILES:
Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1cnnn1CC(F)(F)F |r|
Structure:
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