Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50145722
Substrate
n/a
Meas. Tech.
ChEMBL_153383 (CHEMBL763569)
EC50
5±n/a nM
Citation
 Xu, Y; Rito, CJ; Etgen, GJ; Ardecky, RJ; Bean, JS; Bensch, WR; Bosley, JR; Broderick, CL; Brooks, DA; Dominianni, SJ; Hahn, PJ; Liu, S; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, M; Rungta, DK; Shuker, AJ; Stephenson, GA; Tripp, AE; Wilson, SB; Winneroski, LL; Zink, R; Kauffman, RF; McCarthy, JR Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists. J Med Chem 47:2422-5 (2004) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Peroxisome proliferator-activated receptor | PPAR-alpha | Nuclear receptor subfamily 1 group C member 1 | PPAR alpha/gamma | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor alpha (PPAR alpha) | PPARA_HUMAN | PPARA | NR1C1 | PPAR
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Human
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50145722
Synonyms:
(S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acid | CHEMBL81248
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1oc(nc1CCOc1ccc(C[C@](C)(Oc2ccccc2)C(O)=O)cc1)-c1ccccc1
Structure:
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