Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50578609
Substrate
n/a
Meas. Tech.
ChEMBL_2133588 (CHEMBL4843198)
EC50
0.026303±n/a nM
Citation
 Xing, G; Zhi, Z; Yi, C; Zou, J; Jing, X; Yiu-Ho Woo, A; Lin, B; Pan, L; Zhang, Y; Cheng, M 8-Hydroxyquinolin-2(1H)-one analogues as potential β Eur J Med Chem 224:0 (2021) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_HUMAN | Beta-2 adrenoceptor | ADRB2 | ADRB2R | Beta-2 adrenoreceptor | B2AR
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Human
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50578609
Synonyms:
CHEMBL4863847
Type:
Small organic molecule
Emp. Form.:
C23H29ClN2O4
Mol. Mass.:
432.95
SMILES:
COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1
Structure:
Search PDB for entries with ligand similarity: