Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50348226
Substrate
n/a
Meas. Tech.
ChEMBL_2133992 (CHEMBL4843602)
EC50
2600±n/a nM
Citation
 Vachal, P; Duffy, JL; Campeau, LC; Amin, RP; Mitra, K; Murphy, BA; Shao, PP; Sinclair, PJ; Ye, F; Katipally, R; Lu, Z; Ondeyka, D; Chen, YH; Zhao, K; Sun, W; Tyagarajan, S; Bao, J; Wang, SP; Cote, J; Lipardi, C; Metzger, D; Leung, D; Hartmann, G; Wollenberg, GK; Liu, J; Tan, L; Xu, Y; Chen, Q; Liu, G; Blaustein, RO; Johns, DG Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties. J Med Chem 64:13215-13258 (2021) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 | NR1I2_HUMAN | NR1I2 | PXR | Pregnane X receptor
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Human
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50348226
Synonyms:
CHEMBL1800622
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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