Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM50578849
Substrate
n/a
Meas. Tech.
ChEMBL_2134237 (CHEMBL4843847)
IC50
4260±n/a nM
Citation
 Liu, S; Yuan, D; Li, S; Xie, R; Kong, Y; Zhu, X Synthesis and evaluation of novel and potent protease activated receptor 4 (PAR4) antagonists based on a quinazolin-4(3H)-one scaffold. Eur J Med Chem 225:0 (2021) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2rl3 | PAR-4 | PAR4_MOUSE | Par4 | Proteinase-activated receptor 4 | Thrombin receptor-like 3
Type:
PROTEIN
Mol. Mass.:
42798.57
Organism:
Mus musculus
Description:
ChEMBL_120384
Residue:
396
Sequence:
MCWPLLYPLVLGLSISLAEGIQTPSIYDDVESTRGSHEGPLGPTVELKEPKSSDKPNPRGYPGKFCANDSDTLELPASSQALLLGWVPTRLVPALYGLVVAVGLPANGLALWVLATRVPRLPSTILLMNLAVADLLLALVLPPRLAYHLRGQRWPFGEAACRVATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGQRLTTGLCLVAWLSAATLALPLTLHRQTFRLAGSDRMLCHDALPLTEQTSHWRPAFICLAVLGCFVPLLAMGLCYGATLRALAANGQRYSHALRLTALVLFSAVASFTPSNVLLVLHYSNPSPEAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSHEFREKVRAMLCRQPEASSSSQASREAGSRGTAICSSTLL
  
Inhibitor
Name:
BDBM50578849
Synonyms:
CHEMBL4874590
Type:
Small organic molecule
Emp. Form.:
C20H14ClN3O2S
Mol. Mass.:
395.862
SMILES:
COc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2c1ncn(CC#C)c2=O
Structure:
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