Target
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM50579519
Substrate
n/a
Meas. Tech.
ChEMBL_2135442 (CHEMBL4845052)
IC50
10.0±n/a nM
Citation
 Turdi, HChao, HHangeland, JJAhmad, SMeng, WBrigance, RZhao, GWang, WMoore, FYe, XYMathur, AHou, XKempson, JWu, DRLi, YXAzzara, AVMa, ZChu, CHChen, LCullen, MJRooney, SHarvey, SKopcho, LPanemangelor, RAbell, LO'Malley, KKeim, WJDierks, EChang, SFoster, KApedo, AHarden, DDabros, MGao, QPelleymounter, MAWhaley, JMRobl, JACheng, DLawrence, RMDevasthale, P Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem 64:14773-14792 (2021) [PubMed]  Article 
Target
Name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
2.4.1.143 | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | Gnt2 | MGAT2_RAT | Mannoside acetylglucosaminyltransferase 2 | Mgat2 | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Type:
PROTEIN
Mol. Mass.:
51125.41
Organism:
Rattus norvegicus
Description:
ChEMBL_120420
Residue:
442
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNDALAPPLLDSEPLRGAGHFAASVGIRRVSNDSAAPLVPAVPRPEVDNLTLRYRSLVYQLNFDQMLRNVDKDGTWSPGELVLVVQVHNRPEYLRLLIDSLRKAQGIREVLVIFSHDFWSAEINSLISSVDFCPVLQVFFPFSIQLYPSEFPGSDPRDCPRDLKKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLQDYTGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTLACLPKVWKVLVPQAPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYLFPETLVIGEKFPMAAISPPRKNGGWGDIRDHELCKSYRRLQ
  
Inhibitor
Name:
BDBM50579519
Synonyms:
CHEMBL3912712
Type:
Small organic molecule
Emp. Form.:
C24H21F6N5O2
Mol. Mass.:
525.4463
SMILES:
Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(O)=N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F |r,c:8,17|
Structure:
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