Target
Stanniocalcin-1
Ligand
BDBM201239
Substrate
n/a
Meas. Tech.
ChEMBL_2135458
IC50
0.630000±n/a nM
Citation
 Turdi, HChao, HHangeland, JJAhmad, SMeng, WBrigance, RZhao, GWang, WMoore, FYe, XYMathur, AHou, XKempson, JWu, DRLi, YXAzzara, AVMa, ZChu, CHChen, LCullen, MJRooney, SHarvey, SKopcho, LPanemangelor, RAbell, LO'Malley, KKeim, WJDierks, EChang, SFoster, KApedo, AHarden, DDabros, MGao, QPelleymounter, MAWhaley, JMRobl, JACheng, DLawrence, RMDevasthale, P Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem 64:14773-14792 (2021) [PubMed]  Article
Target
Name:
Stanniocalcin-1
Synonyms:
STC | STC-1 | STC1 | Stanniocalcin-1
Type:
PROTEIN
Mol. Mass.:
27627.69
Organism:
Homo sapiens
Description:
ChEMBL_120405
Residue:
247
Sequence:
MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEEDSPSHIKRTSHESA
  
Inhibitor
Name:
BDBM201239
Synonyms:
US9187424, 6-2
Type:
Small organic molecule
Emp. Form.:
C31H28F6N2O4
Mol. Mass.:
606.5554
SMILES:
COc1ccc(NC(=O)C2=C(C[C@](NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cc1 |r,t:9|
Structure:
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