Reaction Details Report a problem with these data
Target
Stanniocalcin-1
Ligand
BDBM50579526
Substrate
n/a
Meas. Tech.
ChEMBL_2135459 (CHEMBL4845069)
IC50
20±n/a nM
Citation
 Turdi, H; Chao, H; Hangeland, JJ; Ahmad, S; Meng, W; Brigance, R; Zhao, G; Wang, W; Moore, F; Ye, XY; Mathur, A; Hou, X; Kempson, J; Wu, DR; Li, YX; Azzara, AV; Ma, Z; Chu, CH; Chen, L; Cullen, MJ; Rooney, S; Harvey, S; Kopcho, L; Panemangelor, R; Abell, L; O'Malley, K; Keim, WJ; Dierks, E; Chang, S; Foster, K; Apedo, A; Harden, D; Dabros, M; Gao, Q; Pelleymounter, MA; Whaley, JM; Robl, JA; Cheng, D; Lawrence, RM; Devasthale, P Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem 64:14773-14792 (2021) [PubMed]  Article 
Target
Name:
Stanniocalcin-1
Synonyms:
STC-1 | STC1_MOUSE | Stanniocalcin-1 | Stc | Stc1
Type:
PROTEIN
Mol. Mass.:
27487.07
Organism:
Mus musculus
Description:
ChEMBL_120382
Residue:
247
Sequence:
MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSQESA
  
Inhibitor
Name:
BDBM50579526
Synonyms:
CHEMBL4878564
Type:
Small organic molecule
Emp. Form.:
C26H25F6N5O2
Mol. Mass.:
553.4994
SMILES:
Cc1ccc(cc1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F |r,c:8|
Structure:
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