Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50579611
Substrate
n/a
Meas. Tech.
ChEMBL_2135941 (CHEMBL4845551)
IC50
3.9±n/a nM
Citation
 Li, D; Zhang, H; Lyons, TW; Lu, M; Achab, A; Pu, Q; Childers, M; Mitcheltree, MJ; Wang, J; Martinot, TA; McMinn, SE; Sloman, DL; Palani, A; Beard, A; Nogle, L; Gathiaka, S; Saurí, J; Kim, HY; Adpressa, D; Spacciapoli, P; Miller, JR; Palte, RL; Lesburg, CA; Cumming, J; Fischer, C Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors. ACS Med Chem Lett 12:1678-1688 (2021) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50579611
Synonyms:
CHEMBL4871097
Type:
Small organic molecule
Emp. Form.:
C10H18BNO4
Mol. Mass.:
227.065
SMILES:
[H][C@]12C[C@](CCN1)([C@H]2CCCB(O)O)C(O)=O |r,THB:8:7:2:4.5.6|
Structure:
Search PDB for entries with ligand similarity: