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Target
Bromodomain testis-specific protein
Ligand
BDBM50435735
Substrate
n/a
Meas. Tech.
ChEMBL_2145709 (CHEMBL5029989)
Kd
1800±n/a nM
Citation
 Karim, RM; Bikowitz, MJ; Chan, A; Zhu, JY; Grassie, D; Becker, A; Berndt, N; Gunawan, S; Lawrence, NJ; Schönbrunn, E Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J Med Chem 64:15772-15786 (2021) [PubMed]  Article 
Target
Name:
Bromodomain testis-specific protein
Synonyms:
BRDT | BRDT_HUMAN | Bromodomain and extra-terminal motif (BET) | CT9 | Cancer/testis antigen 9 | RING3-like protein
Type:
PROTEIN
Mol. Mass.:
107982.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502985
Residue:
947
Sequence:
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
  
Inhibitor
Name:
BDBM50435735
Synonyms:
CHEMBL2392553
Type:
Small organic molecule
Emp. Form.:
C27H35F2N7O3
Mol. Mass.:
543.6087
SMILES:
COc1cc(ccc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1
Structure:
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